Imec lens-free microscopy leverages super small pixels in modern sensors and currently uses 1um pixel pitch. Imec uses a special multi wavelength laser illumination coupled with holographic SW for image reconstruction. With 1um-small pixels, the resolution is 800nm across 22um2 field of view.
If any CIS manufacturer develops smaller pixels (e.g. 0.6um) with large enough resolution chips (10-20mm2 with 40 to 80MP resolution), there could be a major breakthrough for Imec being able to image and characterize in low cost and compact format bio samples like bacterias, proteins, etc.
Imec demos its lens-free platform in Vimeo video:
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